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- W2361250240 abstract "Objective To investigate the expression of Cyclin D1 in stage T2-3 N0 M0 esophageal squamous cell carcinoma(ESCC) and its relationship with patient prognosis. Methods Expression of Cyclin D1 in 227 ESCC specimens at stage T2-3 N0 M0 was detected by immunohistochemistry(IHC). Receiver operating characteristic(ROC) curve analysis was performed to select the cut-off score for high or low IHC reactivity. Correlations between Cyclin D1 expression and clinicopathological features as well as prognosis of ESCC patients were determined. Results Among the 227 patients,90(39.6%) patients had low expression of Cyclin D1,and 137(60.4%) patients had high expression of Cyclin D1.No signifi cant correlation was observed between Cyclin D1 expression and patient gender(P=0.298),age(P=0.525),tumor location(P= 0.570),tumor length(P=0.056),tumor grade(P=0.713),and depth of invasion(P=0.557). There was signifi cant difference in prognosis between low-expression Cyclin D1 group and high-expression Cyclin D1 group(3-year survival rate:51.1% vs. 43.8%, 5-year survival rate:43.3% vs. 30.7%,P=0.047). Cox proportional-hazards regression model analysis showed that Cyclin D1 was not an independent prognostic factor for ESCC patients at stage T2 ~ 3 N0 M0(relative risk=1.378,95% CI:0.990-1.919,P=0.057). Conclusion Over expression of Cyclin D1 may be an adverse prognostic factor of ESCC patients at stage T2-3 N0 M0." @default.
- W2361250240 created "2016-06-24" @default.
- W2361250240 creator A5081606316 @default.
- W2361250240 date "2014-01-01" @default.
- W2361250240 modified "2023-09-28" @default.
- W2361250240 title "Expression of Cyclin D1 Protein in Stage T_(2-3)N_0M_0 Esophageal Carcinoma and Its Relationship with Prognosis" @default.
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