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- W2361258123 abstract "Aim To design and synthesize 3-alkoxy-11-oxo-β-boswellic ester derivatives using 3-acetyl-11-oxo-β-boswellic acid(AKBA)as leading compound,through the modification on position 3 and position 24 of the structure.Methods Using AKBA as the starting material,the target compounds were synthesized through three-step-process reactions,including chloration,hydrolyzation and alkylation.The ending up of the reaction was determined by TLC.The induced apoptosis activities of the target compounds to NB4 cell were evaluated through AO and EB double decoration assay in vitro and the cell toxicity to NB4 cell were also tested by the MTT assay.Results The chemical structures of the target compounds were confirmed by IR, 1H-NMR, 13C-NMR and MS.The preliminary pharmacological tests showed that compounds 2,3 displayed relatively higher apoptosis activities than that of the lead compound.The cell survival rate of compounds 2 and 3 were improved to some extent comparing with that of AKBA.Conclusion Eight unreported derivatives of boswellic acid were synthesized by this way.Compounds 2 and 3,which were on apoptosis activities and cell toxicity superior to AKBA,are worthy to be intensively studied." @default.
- W2361258123 created "2016-06-24" @default.
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- W2361258123 date "2005-01-01" @default.
- W2361258123 modified "2023-09-24" @default.
- W2361258123 title "Studies on the synthesis and antitumor activities of boswellic acid analogues" @default.
- W2361258123 hasPublicationYear "2005" @default.
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