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- W2361266537 abstract "Palonosetron is a highly selective second-generation 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist (RA) with high binding affinity and long plasma elimination half-life (approximately 40 h). Clinical trials demonstrated that compared with traditional 5-HT3 RAs,a single dose of palonosetron was more effective in preventing acute chemotherapy-induced nausea and vomiting (CINV) ,and it also exhibited prolonged efficacy to provide significantly better protection from CINV in the delayed phases. It was indicated that palonosetron played an important role in preventing postoperative nausea and vomiting. The research progress of palonosetron,such as pharmacodynamics,pharmacokinetics,indication,clinical trials and pharmacoeconomics,is reviewed in the paper." @default.
- W2361266537 created "2016-06-24" @default.
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- W2361266537 date "2009-01-01" @default.
- W2361266537 modified "2023-09-23" @default.
- W2361266537 title "Palonosetron:a second-generation 5-hydroxytryptamine type 3 receptor antagonist" @default.
- W2361266537 hasPublicationYear "2009" @default.
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