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- W2361273022 abstract "Objective: To investigate the expression of nitric oxide synthase in the spinal cord following the blockade of 5-HT2A receptors of inflammatory tissues. Methods: 2% carrageenan was injected subcutaneously into one hindpaw of rats. Vehicle or ketanserin 20 μg and 1% formalin were injected at 1 and 24 h, respectively, after carrageenan in the same site. The rats were perfused at 25 h. The NADPH-diaphorase histochemistry in the spinal cord was determined. Results: Compared to the vehicle treatment, intraplantar injection of 1% formalin in the inflammatory paw produced remarkable increase in NADPH-d reactive neurons that were predominantly distributed in laminae I-II of spinal dorsal horn at L4～L5 segments. The increase was abolished by ketanserin. Interestingly, inhibition of ketanserin on inflammation-evoked increase of NADPH reactivity was reversed by subcutaneous administration of naloxone methiodide, a peripheral opioid receptor antagonist. Conclusion: Peripheral 5-HT plays an important role in the maintenance of inflammatory hyperalgesia, and that blockade of 5-HT2A receptor could activate endogenous opioid analgesia leading to an increase in nitric oxide synthase." @default.
- W2361273022 created "2016-06-24" @default.
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- W2361273022 date "2008-01-01" @default.
- W2361273022 modified "2023-09-23" @default.
- W2361273022 title "EFFECTS OF BLOCKADE OF 5-HT_(2A) RECEPTORS IN THE INFLAMMATORY TISSUES ON THE EXPRESSION OF NITRIC OXIDE SYNTHASE IN THE SPINAL CORD OF RATS" @default.
- W2361273022 hasPublicationYear "2008" @default.
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