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- W2361284572 abstract "Objective To study the mechanisms of treating severe acute pancreatitis (SAP) with continuous blood purification (CBP). Methods 10 SAP patients were chosen and treated with CBP. Blood biochemical index, routine, gas analysis and tumor necrosis factor-α(TNF-α) were tested in pre-,intra- and post-treatment of CBP. Meanwhile, APACHEⅡ, SAPSⅡ and MODS score were graded. Results Compared with pre-treatment, APACHEⅡ, SAPSⅡ and MODS scores decreased on the second morning of intra-treatment and the next morning of post-treatment. Oxygenation index (FiO 2/PO 2) was improved obviously. Pressure-adjusted heart rate (PAHR) during treatment were decreased. It was positive correlation with the amount of dehydration by CBP that the difference of the PO 2/FiO 2 and PAHR between the next morning pretreatment and intra-treatment. The amount of dehydration was negative correlation with MODS score on the second morning during treatment. BUN, Cr and uric acid was decreased during CBP and the longer time was, the lower scores were. TNF-α was not decreased significantly after treatment. Conclusions The improvement of cardiac and pulmonary function was concerned with relieving interstitial edema of organization after dehydration by CBP. But it is not right that the more dehydration was, the better patient was. The longer time was better for clearing BUN and Cr. The time of CBP should be shortened for the patients with normal BUN and Cr. The mechanisms of treating SAP with CBP was the removal of TNF-α which was not supported according to the changes of TNF-α before, during and after treatment." @default.
- W2361284572 created "2016-06-24" @default.
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- W2361284572 date "2004-01-01" @default.
- W2361284572 modified "2023-09-24" @default.
- W2361284572 title "Mechanisms of treating severe acute pancreatitis with continuous blood purification" @default.
- W2361284572 hasPublicationYear "2004" @default.
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