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- W2361285809 abstract "The effect of gene copy number and chromosomal position on heterologous gene expression in Saccharomyces cerevisae has been tentatively investigated using a modified hepatitis B virus surface antigen SA-28 gene. The plasmids containing different copies of SA-28 gene expression cassette were integrated into different chromosomal loci via FLP recombinase mediated targeted integration. The expression of SA-28 gene in the resultant transformants was then measured. The result indicated that the expression of SA-28 gene was positively related to the gene dosage at HIS3 locus and had chromosomal polarity at several chromosomal loci." @default.
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- W2361285809 date "2000-03-01" @default.
- W2361285809 modified "2023-09-23" @default.
- W2361285809 title "[Effects of gene copy number and chromosomal position on the expression of a modified HBsAg gene SA-28 in yeast]." @default.
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