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- W2361296723 abstract "AIM To develop a less toxic alternative for sandimmun neoral (Neoral). To study the preparation conditions and to compare its pharmacokinetic characteristics with Neoral. METHODS Polylactide nanoparticles loaded cyclosporine A was prepared by solvent-nonsolvent method. Polylactide nanoparticles were administered by oral in a dosage of 15 mg.kg-1. The CyA concentration in whole blood sample was determined by HPLC. RESULTS The quantities of CyA, PLA and volume of acetone added had significant influence on the NP diameters. Under proper condition, the nanoparticles with diameters of 57.5 nm were obtained. The relative bioavailability in rats was 101.6%, with a smaller absorption rate (P < 0.05) and a smaller elimination rate (P < 0.1). CONCLUSION The nanoparticles (diamater < 100 nm) with relative high bioavailability were prepared using solvent-nonsolvent method. It is suitable for further study." @default.
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- W2361296723 date "2004-01-01" @default.
- W2361296723 modified "2023-09-22" @default.
- W2361296723 title "Study on preparation conditions for polylactide nanoparticles loaded cyclosporine A and its oral bioavailability in rats" @default.
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