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- W2361312233 abstract "Objective To searchfortheinheritedmarkersoffamilial type 2 diabetes mellitus. Methods Erythrocyte sodium lithium counter transport activity (SLCA) was measured according to the method described by Fujitain22familialtype2 DM patients (with 2 or more type 2 DM patients in the family), their 27 non diabetic first degree relatives, and 40 healthy control subjects. Results SLCA was significantly higher in familial type 2 DM patients (0.310±0.101)mmol·L -1 ·RBC -1 ·h -1 andtheirnon diabeticfirst degree relatives (0.274±0.112)mmol·L -1 ·RBC -1 ·h -1 than in healthy control subjects (0.191±0.083)mmol·L -1 ·RBC -1 ·h -1 (P0.01) ,no significant difference being found between familial type 2 DM patients and their first degree relatives (P0.05). A stepwise multiple regression analysis was conducted using SLCA and insulin sensitivity index (ISI) as the dependent variables respectively. It was found that SLCA correlated negatively with ISI andHDL 2 (P0.01,P0.05,respectively).Onthis model, ISI had the greatest influence (39.7%) on SLCA, and 42.5% of the variance in SLCA was explained by ISI and HDL 2. SLCA also had influence (55.7%) on ISI. Conclusion Erythrocyte SLCA increases significantly in familial type 2 DM patients and their first degree relatives and erythrocyte SLCA activity can be used as one of the indices for evaluation of insulin sensitivity as well as one of the inherited markers of familial type 2 DM." @default.
- W2361312233 created "2016-06-24" @default.
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- W2361312233 date "1999-01-01" @default.
- W2361312233 modified "2023-09-23" @default.
- W2361312233 title "Erythrocyte sodium lithium counter transport activity and insulin resistance in familial type 2 diabetes mellitus pedigrees" @default.
- W2361312233 hasPublicationYear "1999" @default.
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