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- W2361332016 abstract "Objective To observe the effects of lipopolysacharide(LPS) on the expression of nNOS and c-Fos in hippocamapl CA2~3 regions and investigate the roles of NO and c-Fos in the neuroimmunomodulation of hippocampal CA2~3 regions.Methods SD rats of experiment group were intraperitoneally injected by LPS,control rats were treated by normal saline. 2.5h after treatment,RT-PCR was used to detect the expression of nNOS mRNA,in situ hybridization to detect c-FosmRNA,and immunohistochemistry to detect nNOS and c-Fos.Results The optic density(OD) values of nNOS,cFos and their mRNAs in rat hippocampal CA2~3 regions were showed as follows: nNOS mRNA(0.283±0.09,0.476±0.03),nNOS(0.653±0.97,1.155±0.12),c-Fos mRNA(1.031±0.99,1.326±0.91),c-Fos(0.426±0.16,0.830±0.14) in control and LPS groups respectively.The present results indicate that LPS upregulates the expressions of nNOS,c-Fos and their mRNA in rat hippocampal CA2 and CA3 areas.Conclusion Rats hippocampal CA2 and CA3 regions play an important role in the immunomodulating process in which NO and c-Fos are closely involved." @default.
- W2361332016 created "2016-06-24" @default.
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- W2361332016 date "2005-01-01" @default.
- W2361332016 modified "2023-09-28" @default.
- W2361332016 title "Effects of Immune Stimulation on the Expression of nNOS and c-Fos in Hippocampal CA2 and CA3 Regions of Rat" @default.
- W2361332016 hasPublicationYear "2005" @default.
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