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- W2361337869 abstract "Objective To explore the mechanisms of Shashen Maidong Decoction on prevention and treatment on radiation pneumonitis via observing the influences of Shashen Maidong Decoction on SOD activity,MDA content of lung tissue in radiation pneumonitis rats.Methods 141 male SD rats of clean grade were randomly divided into normal control group,model group,Shashen Maidong Decoction prevention group,Shashen Maidong Decoction treatment group,dexamethasone treatment group,in which the control group contained 21 rats and other groups were 30.In addition to the normal control group,other groups were given chest X-ray single-wide exposure 20Gy.Apart from Shashen Maidong Decoction prevention group started 1 week before radiation fed Shashen Maidong Decoction,the rest of the group the next day after modeling,the normal control group,model group were given the same volume of normal saline,Shashen Maidong Decoction treatment group fed Shashen Maidong Decoction,dexamethasone treatment group were given dexamethasone suspension once a day.At 2,4 and 6 weeks after irradiation,in addition to the normal control group were 7,the rest of the group of 10 rats were randomly sampled in vivo.10% solution of chloral hydrate anesthetized rats were injected intraperitoneally,exposed chest,take the right lung tissues were homogenized in the supernatant,the use of SOD activity of xanthine oxidase method,using thiobarbituric acid colorimetric Determination of MDA.Results Compared with normal control rats,SOD activity decreased in lung tissue(P0.01),MDA content increased(P0.05).Compared with model group,Shashen Maidong Decoction prevention group,Shashen Maidong Decoction treatment group,dexamethasone treatment in lung tissue SOD activities increased(P0.01),MDA content decreased(P0.01).In Shashen Maidong Decoction prevention group the SOD activity was higher than the Shashen Maidong Decoction treatment group,dexamethasone treatment group(P0.01),MDA content was lower than in Shashen Maidong Decoction treatment group,dexamethasone treatment group(P0.01).Shashen Maidong Decoction treatment group SOD activity was higher than that in dexamethasone treatment group(P0.01),MDA content was lower than that in dexamethasone treatmentgroup(P0.05).Conclusion Shashen Maidong Decoction enhances the anti-oxidation of lung tissue via inhibiting lipid peroxidation and enhancing SOD activity for antagonizing the strong lipid peroxidation in the radiation pneumonitis.And the preventive effect of this prescription is superior to its therapeutic effect." @default.
- W2361337869 created "2016-06-24" @default.
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- W2361337869 date "2011-01-01" @default.
- W2361337869 modified "2023-09-23" @default.
- W2361337869 title "Infuences of Shashen Maidong Decoction on SOD Activity and MDA Content of Lung Tissue of Radiation Pneumonitis Rats" @default.
- W2361337869 hasPublicationYear "2011" @default.
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