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- W2361341057 abstract "Objective To explore the effects and possible mechanisms of sulforaphane on focal cerebral ischemia/reperfusion injury in rats.Methods Focal cerebral ischemia in rats was induced by 24h occlusion of the middle cerebral artery(MCAO).The administration doses of 2.5mg/kg,5mg/kg and 10mg/kg of SFN were provided at 1h after the onset of ischemia through intraperitoneal injection.The infarct area was measured by 2,3,5-triphenyltetrazolium chloride(TTC)staining.The neurological deficit score and brain edema were examined.The activities of antioxidase SOD and contents of MDA in ischemic brain tissue were analyzed.The expression of NQO1 and Prdx6 were detected by immunofluorescence.Results All the sulforaphane groups may reduce the neurological deficit score,infarct size and brain edema,especially the 5mg/kg sulforaphane group showed significant reduced neurological deficit score,infarct size and brain edema.Striking increase in activities of SOD and significant decrease in contents of MDA in rats were also observed after 24h of MCAO.The expression of NQO1 and Prdx6 was remarkably increased by sulforaphane.Conclusion Sulforaphane has valid protective effect on cerebral ischemia/reperfusion injury.Sulforaphane plays satisfactory neuroprotective effect after focal cerebral ischemia-reperfusion injury which may be associated with up-regulating the expression of NQO1 and Prx6." @default.
- W2361341057 created "2016-06-24" @default.
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- W2361341057 date "2012-01-01" @default.
- W2361341057 modified "2023-09-28" @default.
- W2361341057 title "Neuroprotective effect and possible mechanisms of sulforaphane on focal cerebral ischemic-reperfusion injury in rats" @default.
- W2361341057 hasPublicationYear "2012" @default.
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