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- W2361342638 abstract "Objective: To investigate the clinical significance of human herpesvirus-6's(HHV-6)infection and its correlation to oral malignancy. Methods: Samples of saliva, peripheral blood mononuclear cells (PBMCs), cancer tissue and normal tissue collected from 40 patients with oral malignancy and 40 healthy young adults were tested for human herpesvirus-6 by nested PCR assays. Results: HHV-6 DNA positive rates were 85.0% and 45.0% in the salivas of patients and control group respectively, 67.5% and 22.5% in the PBMCs of patients and control group respectively, both of which demonstrated statistical difference. In both groups HHV-6 DNA positive rates in saliva were higher than those in PBMCs. The positive rate in cancer tissues(78.95%) was significantly higher than that of normal tissues(10.53%). Conclusion: The result confirms that saliva gland is the latenty and proliferation position of HHV-6 and saliva is the predominant transmission route of HHV-6. The infection of HHV-6 correlates to oral malignancy, which suggests HHV-6 may play a role in the occurrence and cell transformation of malignancy." @default.
- W2361342638 created "2016-06-24" @default.
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- W2361342638 date "2005-01-01" @default.
- W2361342638 modified "2023-09-23" @default.
- W2361342638 title "The Correlation between Human Herpesvirus-6 (HHV-6) and Oral Malignancy." @default.
- W2361342638 hasPublicationYear "2005" @default.
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