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- W2361357181 abstract "Objective: To develop a HPLC-MS/MS method for melitracen assay in plasma and its bioequivalence. Methods: Melitracen was extracted with ethyl acetate-dichloromethane. The residues were analyzed with a HPLC-MS/MS system (Agilent ZORBAX Eclipse Plus C18 , 4.6 mm×150 mm, 5 μm) with the mobile phase composed of acetonitrile (1 % formic acid) with 0.02 mol·L-1 ammonium formate (80:20, v/v). Agilent 6410 triple quad mass spectrometer system equipped with an electrospray ionization ion-trap source was used as the detector and operated in the positive ion mode. Selected reaction monitoring (SRM) using the precursor to product ion combinations of m/z 292.2→232.2 and m/z 278.1→91.0 was performed to detect melitracen and the internal standard, respectively. Results: The average recoveries for melitracen were 97.53 %, 104.03 % and 106.87 % respectively. The within-day (n=5) and between-day (n=3) precision was less than 15 %. The calibration curves for melitracen had good linearity over the range of 0.2~60μg·L-1 with r = 0.9986 (n=9). The limits of quantitation for melitracen was 0.2 μg·L-1. Conclusions: This paper provides a sensitive, accurate, precise and reliable analytical procedure for clinical monitoring of melitracen plasma and its phamacokinetic studies." @default.
- W2361357181 created "2016-06-24" @default.
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- W2361357181 date "2009-01-01" @default.
- W2361357181 modified "2023-09-25" @default.
- W2361357181 title "Rapid determination of melitracen in plasma by HPLC-MS/MS and its bioequivalence" @default.
- W2361357181 hasPublicationYear "2009" @default.
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