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- W2361372810 abstract "Objective:To investigate the roles of protein kinase C in the changes of cytosolic calcium induced by Aβ and the intervention effects of Stilbene glucoside(TSG).Methods:Rats were randomly divied into three group: control group,AD model group(Aβ1-42 injection into the rat of hippocampus),TSG(treated with TSG.following Aβ1-42 injection into the rat of hippocampus) group,to observe the effect of TSG on the expression and activation of PKC detected with western blot and phosophorus radioisotope assay.Relative concentration of intracellular calcium was monitored by means of immunofluorescence under laser scanning confocal microscope.Results:Compared with the control group,calcium overload was confirmed by means of immunofluorescence under laser scanning confocal microscope;the expression and activation of PKC was increased.Result showed that TSG can decrease levels of intracellular calcium(P0.05).The expression and activation of PKC were down regulated(P0.05).Conclusions:The disorder of intracellular calcium homeostasis caused by Aβ might involve the pathway of PKC.TSG can protect neurons from Aβ toxicity by maintaining the calcium homeostasis." @default.
- W2361372810 created "2016-06-24" @default.
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- W2361372810 date "2011-01-01" @default.
- W2361372810 modified "2023-09-30" @default.
- W2361372810 title "The role of protein kinase C in calcium homeostasis induced by Aβ and intervention effects of stilbene glucoside" @default.
- W2361372810 hasPublicationYear "2011" @default.
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