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- W2361375931 abstract "Objective :To investigate the roles of ependymocytes of the subfornical organ (SFO) in rats with experimental allergic encephalomyelitis(EAE) by viewing their dynamic morphology changes. Methods : The ependymocytes of SFO were observed in latency, attack, and remission stages of EAE by LM, SEM and TEM. Results : (1) Damage of SFO ependymocytes occurred earlier than onset of EAE and severity of the damage was corresponding to the stages of EAE. (2) During remission stage, regenerated cells were found in subependymal layer, which lined compactly and included high density of chromatin. Conclusion : The results may suggest that SFO takes part in immune reaction in the brain during EAE, and that it is one of the earlier damaged region. Since SFO is devoid of BBB, those inflammatory cells or molecules may enter the brain easier and faster through it. The subependymal cells , which belong to stem cells, are activated to replace the damaged ependymocytes in EAE, but their detailed effects are not clarified yet." @default.
- W2361375931 created "2016-06-24" @default.
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- W2361375931 date "2003-01-01" @default.
- W2361375931 modified "2023-09-25" @default.
- W2361375931 title "Morphological changes of ependymocytes in subfornical organ in rats with experimental allergic encephalomyelitis" @default.
- W2361375931 hasPublicationYear "2003" @default.
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