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- W2361381639 abstract "Objective To study the inhibitory effect of Survivin antisense oligonucleotide (ASODN) on human gastric carcinoma cell HS-746T.Methods The designed and synthesized Survivin ASODN was transfected into gastric carcinoma cells.The cultured cells were divided into 6 groups:blank,liposomes and sense oligonucleotide (SODN);100,200 and 400 nmol/L ASODN.The cell ultrastructure was observed under transmission electron microscopy.Apoptotic index (AI) was examined by flow cytometry.The colorimetric MTT assay was used to detect the cell inhibition ratio (RI).Changes of Survivin gene transcription and protein expression were detected by RT-PCR and Western blot.Results The contents of gastric carcinoma cell Survivin mRNA and protein were decreased in anisoconcentration Survivin ASODN groups,while apoptotic cells increased.AI in 100,200 and 400 nmol/L ASODN groups 24 h after transfection was 14.8%, 19.4% and 53.8% respectively,and IR (%) of those was 45.98± 2.99, 50.96± 3.38, 72.79± 2.48 respectively.The AI and IR in ASODN groups were higher than in control groups.Conclusion Survivin ASODN can inhibit the proliferation of gastric carcinoma cells." @default.
- W2361381639 created "2016-06-24" @default.
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- W2361381639 date "2005-01-01" @default.
- W2361381639 modified "2023-09-28" @default.
- W2361381639 title "Inhibition of Survivin antisense oligonucleotide against human gastric carcinoma cell HS-746T" @default.
- W2361381639 hasPublicationYear "2005" @default.
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