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- W2361399327 abstract "Objective To investigate the relations between serum sclerostin and coronary arterycalcification score( CACS)or ossification process in ankylosing spondylitis( AS),and to find the risk factors for coronary artery calcification inpatients with AS. Methods Seventy-five AS patients( AS group) and Seventy healthy persons( control group) were enrolled in this study. The serum sclerostin was measured by enzyme-linked immunosorbent assay method. CACS was calculated by 64-slice spiral CT,PWV was measured by non-invasive vascular screening device. The modified Stoke AS Spine Score( m SASSS) was applied to evaluateossification in the spine of AS patients. The clinical indices( age,gender,course of disease,and disease activity) and indices of inflammation,including erythrocyte sedimentation rate( ESR) and C-reactive protein( CRP),were evaluated or measured. The relationship between sclerostin and clinical indexes,radiographic scoring,indices in inflammation,was estimated by SPSS software,and the diagnostic value of sclerostin was analyzed by receiver operator characteristic( ROC) curve. Results The levels of serum sclerostin in AS patients were significantly lower than those in healthy controls( P 0. 01),There was no significant correlation between sclerostin and ESR,CRP and BASFI score( P 0. 05). Spearman analysis showed that PWV,CACS or m SASSS were significant negatively correlated with serum sclerostin( P 0. 05) in AS Group. The mean CACS and PWV in AS group was significantly higher than that in control group. ROC curve revealed that theoptimal sclerostin value of CAC was 54. 3( AUC = 0. 82,95% CI: 0. 71- 0. 87) with a sensitivity of 60% and a specificity of 81%. Serum sclerostin remained asindependent predictor of CACS and m SASSS in multivariate analysis( P 0. 05). Conclusion Serum sclerostin is correlated with IMT and can thus be considered as an independent predictor for CAC. Serum sclerostin may serve as adiagnostic biomarker of AS." @default.
- W2361399327 created "2016-06-24" @default.
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- W2361399327 date "2015-01-01" @default.
- W2361399327 modified "2023-09-23" @default.
- W2361399327 title "The study of association between serum sclerostin and coronary artery calcification score in patients with ankylosing spondylitis" @default.
- W2361399327 hasPublicationYear "2015" @default.
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