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- W2361402292 abstract "Mouse embryonic stem cells possess two kinds of pluripotent states,naive pluripotent state and primed pluripotent state. The two cell types differ in colony morphology,self-renewal maintaining condition,gene expression,epigenetic features and single cell cloning efficiency. Human embryonic stem cells( h ESCs) with the traditionally culture condition closer to the primed pluripotent state,and are difficult to achieve and maintain the naive pluripotent state without genetic modifications. Here we successfully converted the already established primed h ESCs to naive h ESCs with small chemical molecules under specific culture system. The converted h ESCs showed domed-shaped colonies,had two activated X chromosomes and high single cell cloning efficiency,as well as molecular characteristics,and epigenetic feature was closer to the naive pluripotent state. The Results suggest that h ESCs can possess different pluripotent characteristic without genetic modification when cultured under the specific conditions in vitro. The naive pluripotent h ESCs has broad application prospects in developmental mechanism research and clinical applications such as gene therapy,organ regeneration. The cultivation method of small molecules without gene manipulation has greatly increased the security of naive pluripotent stem cell application." @default.
- W2361402292 created "2016-06-24" @default.
- W2361402292 creator A5056459691 @default.
- W2361402292 date "2014-01-01" @default.
- W2361402292 modified "2023-09-26" @default.
- W2361402292 title "Transformation from Primed to Naive Pluripotent State of Human Embryonic Stem cells by Small Chemical Molecules" @default.
- W2361402292 hasPublicationYear "2014" @default.
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