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- W2361424881 abstract "Objective To evaluate the radio-sensitization effect and side effect of paclitaxel(PTX) versus sodium glycididazole(CMNa) in local advanced nasopharyngeal carcinoma.Methods 82 patients were randomly divided into the PTX group(n=42) and the CMNa group(n=40).The PTX group was received 60 mg/m2 of PTX via intravenous infusion,every 10 days for 5 times in the radiotherapy duration.The CMNa group received injections of CMNa at a dose of 0.75-1.0g before the radiotherapy 3 times per week for 7 weeks.All patients received conventional fractionation radiotherapy.Results There was no significant difference in complete tumor remission between the two groups at the end of the therapy and 3 months after radiotherapy.The median follow-up times was 20 months.The metastasis rate in the PTX group(28.6%) was significantly lower than in the CMNa group(50.0%)(P0.05).The regional recurrence rate was lower in the PTX group than in the CMNa group,but there was no significant difference(P0.05).Oral cavity mucositis in grades 2 and 3 and leukopenia in the PTX group were more frequent than in the CMNa group(P0.01).Conclusion Small dose paclitaxel was similar to CMNa in radio-sensitization efficiency for local advanced nasopharyngeal carcinoma,and paclitaxel plus radiotherapy could reduce metastasis,but increase some acute toxicities,especially in oral cavity mucositis and leukopenia." @default.
- W2361424881 created "2016-06-24" @default.
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- W2361424881 date "2011-01-01" @default.
- W2361424881 modified "2023-09-23" @default.
- W2361424881 title "Radio-sensitization effect of paclitaxel versus sodium glycididazole for local advanced nasopharyngeal carcinoma" @default.
- W2361424881 hasPublicationYear "2011" @default.
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