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- W2361429940 abstract "Objective: To evaluate the correlations of microvessel density(MVD),vascular endothelial growth facor(VEGF),Hypoxia inducible factor 1 alpha(HIF-1α) and P53 protein with clinical significance in laryngeal carcinoma.Method: Surgically resected specimens of 64 laryngeal carcinomas were studied by immunohistochemical stainning for VEGF,HIF-1α,P53 protein and MVD.Result: Positive expressions of VEGF,HIF-1α,P53 protein,were found in 71.88%,65.63%,and 62.50% of laryngeal carcinoma specimens,respectively.The mean MVD in this series was 35.79±9.49.The expression of P53 and HIF-1 was positively correlated with VEGF expression((r =0.323,P=0.0090.01;r =0.305,P=0.0140.05).The expression of HIF-1 was positively correlated with VEGF expression(r =0.279,P=0.0260.05)).The expression of P53,HIF-1α,VEGF was significantly and positively correlated with lymph nod metastasis.The microvessel density(MVD) in P53-or HIF-1α and positive tumors was significantly higher in patients with cervical lymph node metastasis than those without metastasis(P0.05).Conclusion: The P53 protein,HIF-1α,VEGF may play an important role in the angiogenesis of laryngeal carcinoma.Furthermore,VEGF and HIF-1α expression may be regulated by P53,metastasis in the process of laryngeal cancer cell spreading to cervical lymph nodes." @default.
- W2361429940 created "2016-06-24" @default.
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- W2361429940 date "2008-01-01" @default.
- W2361429940 modified "2023-09-24" @default.
- W2361429940 title "Clinical Significance of Microvessel Density and Angiogenesis-related Factors Expression in Laryngeal Carcinoma" @default.
- W2361429940 hasPublicationYear "2008" @default.
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