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- W2361431472 abstract "OBJECTIVE:To study the expressions of RASSF1A,Cyclin D1 and Bcl-2 in transitional cell carcinoma of bladder,and study the relationship among RASSF1A protein and Cyclin D1 protein,Bcl-2 protein.METHODS:The expressions of RASSF1A protein,Cyclin D1 protein and Bcl-2 protein in transitional cell carcinoma of bladder,mucous in the paracarcinoma and normal mucous of urinary bladder,were detected by the immunohistochemical staining SP method.RESULTS:The positive expressions of RASSF1A protein,Cyclin D1 protein and Bcl-2 protein by immunohistochemistry were 46.7%(21/45),88.9%(40/45)and 57.8%(26/45)in transitional cell carcinoma of bladder,84.4%(38/45),42.2%(19/45),24.4%(11/45)in paracarcinoma mucous,94.4%(17/18),38.9%(7/18),16.7%(3/18)in normal mucous of urinary bladder,respectively.The expression of RASSF1A protein was significant lower in transitional cell carcinoma of bladder tissues than those in paracarcinoma mucous and normal mucous of urinary bladder,P0.05.The expression of Cyclin D1 protein and Bcl-2 protein were significantly higher in transitional cell carcinoma of bladder tissues than those in paracarcinoma mucous and normal mucous of urinary bladder,P0.05.There was a negative correlation among RASSF1A protein and Bcl-2 protein,Cyclin D1 protein in transitional cell carcinoma of bladder tissues,P0.05.CONCLUSIONS:The abnormal expressions of RASSF1A protein,Cyclin D1 and Bcl-2 protein maybe have highly correlation with the oncogenesis and development of bladder cancer.RASSF1A protein may increase the expression of Cyclin D1 protein and Bcl-2 protein in some ways,and then lead to the oncogenesis and development of bladder cancer." @default.
- W2361431472 created "2016-06-24" @default.
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- W2361431472 date "2007-01-01" @default.
- W2361431472 modified "2023-09-27" @default.
- W2361431472 title "Expressions of RASSF1A,Cyclin D1,Bcl-2 and their significance in transitional cell carcinoma of bladder" @default.
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