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- W2361459218 abstract "Objective To explore the influence and curative effect of Montelukast on plasma TGF-β1 and urine LTE4 levels asthma patients during acute attack. Methods 72 mild to moderate asthma patients during acute attack from April 2011 to April 2013 collected by Xianju People's Hospital were divided into observation group and control group randomly. All the patients got fundamental treatment as anti-infection, spasmolysis, antiasthma and inhalation. And the patients in observation group got extra treatment as taking Montelukast Sodium Chewable Tablets 10 mg per time, once a day, for 4 weeks. The plasma TGF-β1 and urine LTE4 levels were observed before and after treatment in two groups. The curative effect and adverse drug reactions were analyzed also. Results The plasma TGF-β1 and urine LTE4 levels in two groups [(78.72±20.46),(117.64±32.75) pg/mL,(187.21±56.74),(258.75±47.95) ng/L] were decreased significantly comparing with 4 weeks before treatment [(147.25±43.27),(150.26±41.62) pg/mL,(321.72±74.35),(319.22±81.62) ng/L](P 0.01 or P 0.05), and the rangeabilities in observation group were more significantly obviously than that in control group(P 0.05). The total clinic effective rate in observation group(91.67%) was significantly higher than that in control group(72.22%)(χ2=4.60, P 0.05). No obviously adverse drug reactions were found during the therapy period in two groups. Conclusion Treating mild may be to moderate asthma during acute attack, with Montelukast shows a good curative effect and safety. Its mechanism may be related to down-regulating the plasma TGF-β1 and urine LTE4 levels." @default.
- W2361459218 created "2016-06-24" @default.
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- W2361459218 date "2014-01-01" @default.
- W2361459218 modified "2023-09-27" @default.
- W2361459218 title "The influence and curative effect of Montelukast on plasma TGF-β1 and urine LTE4 levels of asthma patients during acute attack" @default.
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