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- W2361460012 abstract "Objective] To evaluate the effects of angiotensin (1 7) on myocardial ischemia reperfusion injury in isolated rat hearts. In the langendorff' s perfused rat hearts, local ischemia was induced by coronary ligation for 15 minutes. After ischemia, the hearts were reperfused for 30 minutes. Ang (1 7) was used in the perfusion solution. The effects of Ang (1 7) on reperfusion arrhythmias ,left ventricular systolic pressure(LVSP) and coronary flow were investigated. Ang (1 7) produced a significant reduction in the index of severity of reperfusion arrhythmias(4.0± 2.3 vs 6.8± 2.2,P 0.05). Ang (1 7) had no effect on LVSP during the period of occlusion, but it prevented further reduction of LVSP during the reperfusion period. It also improved coronary flow during the reperfusion period. The effects of Ang (1 7) on the reperfusion arrhythmias and LVSP were blocked by indomethacin pretreatment.But indomethacin pretreatment did not change the effect of Ang (1 7) on coronary flow.[ Conclusion] Angiotensin (1 7) can protect myocardium from ischemia reperfusion injury." @default.
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- W2361460012 date "2003-01-01" @default.
- W2361460012 modified "2023-09-24" @default.
- W2361460012 title "Effects of Angiotensin-(1-7) on Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts" @default.
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