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- W2361462654 abstract "Objective: To evaluate the changes of tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) with zocor Simvastatin on renal injury in rats fed with hypercholesterol diet, and to study the preventing effects of zocor Sinvastatin.Methods: Thirty male Wistar rats were randomly divided into the control group (n=10, a normal diet), hyperlipidemia group (n=10, fed with high-cholesterol diet) and treatment group (n=10, high-cholesterol diet + 2.5mg/(kg·d) zocor Simvastatin).During the testing of 12 weeks, serum lipids, urinary N-acetyl-beta-D-glucosaminidase (NAG) and 24-hour urinary protein excretion (UPE) were compared among the three groups.In addition, the level of TNF-α in serum, urine and renal homogenate, and the level of MDA in serum and renal cortex were also detected.Results: After 12 weeks of treatment with Simvastatin, the level of serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) decreased (P0.01).Urinary NAG and UPE decreased also compared with the hyperlipidemia group (P0.01).The TNF-α levels in urine and renal homogenate were decreased significantly, and the MDA level in renal cortex was also markedly decreased (P 0.05).Conclusion: Simvastatin could effectively improve the hyperlipidemia, and decrease TNF-α and MDA; the changes of TNF-α and MDA may play a role in the pathogenesis and progress of hyperlipidemia induced renal injury." @default.
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- W2361462654 date "2006-01-01" @default.
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- W2361462654 title "Effects of Zocor Simvastatin on Tumor Necrosis Factor-alpha and Malondialdehyde in Rats with Renal Injury Induced by Hyperlipidemia" @default.
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