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- W2361477887 abstract "Objective To establish a slowly progressive reproducible rabbit model of intervertebral disc degeneration induced by puncturing the annulus fibrosus with needles of defined gauges and aspirating some nucleus pulposus tissue from the intervertebral discs(IVDs).Methods The L3-4、L4-5 and L5-6 lumbar intervertebral discs of 18 New Zealand white rabbits were stabbed by 21-gauge hypodemic needle into a depth of 5 mm in the antero annulus fibrosus,the needle valve was pulled out,and some nucleus pulposus tissue aspirated out.Magnetic resonance imaging scans(MRI) and computed radiography(CR) analysis of the stabbed discs and intact L2-3 disc were performed preoperatively and at the 4th,8th,12th week respectively after surgery.Results In the MRI the stabbed discs a progressive decrease of sigal intensity was exhibited in T2-weighted images which start at the 4th week after stabing and last for 12 weeks.CR analyses indicated progressive decrease of the disc height index(P0.01).Conculation The stabbing and asprirating approach results in a slowly progressive intertebral disc degeneration in rabbit model.This model is available for studying the status of intervertebral disc dege-neration and treatment." @default.
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- W2361477887 date "2007-01-01" @default.
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- W2361477887 title "Animal model development and imaging analysis of the degenerative disc in rabbit" @default.
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