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- W2361486230 abstract "Objective: To investigate the effects of Tripterygium Wilfordii concentrate-granules on the proteinuria and urinary podocytes in patients with IgA nephropathy(IgAN).Methods: Sixty-four patients with IgAN were randomly divided into treatment group(n=32)and control group(n=32).Besides the western medical therapies on all the patients,the treatment group was treated by Tripterygium Wilfordii concentrate-granules(20 g/d) and the control group was treated by placebo(20 g/d).The positive rate and amount of urinary podocytes,24 h urine protein quantitation(UPQ),and the expression of nephrin in urinary sediment were observed.The therapeutic effects on proteinuria were evaluated.Results: As for the therapeutic effects on proteinuria,the total effective rates of treatment group and control group were 78.1% and 43.8% respectively,with a statistical difference between two groups(P0.01).Eight,sixteen and twenty-four weeks after treatment,the amount of urinary podocyte and the UPQ in treatment group significantly decreased compared with before treatment(P0.05) and compared with control group at the same stage(P0.05);sixteen and twenty-four weeks after treatment,the positive rate of urinary podocyte in treatment group obviously decreased compared with before treatment(P0.05),and twenty-four weeks after treatment,the positive rate of urinary podocyte of treatment group was lower than that of control group(P0.05);twenty-four weeks after treatment,the amount of urinary podocyte and the UPQ in control group significantly decreased compared with before treatment(P0.05).After treatment,the level of nephrin expression in urinary sediment and the ratio of urinary nephrin/creatinine in both groups significantly decreased compared with before treatment(P0.01),and the treatment group decreased more obviously than control group(P0.01).Conclusion: The Tripterygium Wilfordii concentrate-granules can obviously reduce the excretion of urine protein of patients with IgA nephropathy,and its mechanism may have relationship with improving the podocyte injury and decreasing the excretion of urinary podocyte." @default.
- W2361486230 created "2016-06-24" @default.
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- W2361486230 date "2011-01-01" @default.
- W2361486230 modified "2023-09-25" @default.
- W2361486230 title "Effects of Tripterygium Wilfordii Concentrate-granules on Proteinuria and Urinary Podocytes in Patients with IgA Nephropathy" @default.
- W2361486230 hasPublicationYear "2011" @default.
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