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- W2361489054 abstract "Objective To study the clinicopathological,immunohistochemical and prognosis of Langerhans cell tumor with sarcomatoid features.Methods The clinical data,histopathological,immunophenotype and prognosis of a case of Langerhans cell tumor with sarcomatoid features at thoracic vertebrae were studied and relatively literatures were reviewed.Results A 15-year-old girl presented as an osteolytic lesion at thoracic vertebrae with scoliosis.Microscopically,the tumor was predominantly composed of sheets or nests of large epithelioid cells with central necrosis and focal infiltration of a small number of eosinophils.The pleomorphic neoplastic cells had large oval to convoluted nuclei with coarsed chromatin or nuclear groves,abnormal mitosis could be seen.These morphologic features above suggested this was a malignant tumor.A broad panel of immunohistochemical stains were performed and showed that the tumor cells were positive for CD1a,Langerin,CD68,CD56,CD4 and vimentin focally,negative for CD3,CD20,CD30,CD43,CD123,TCL-1,Syn,CgA,MPO,CK,EMA,TG,α-inhibin,P53,Des,CMV and RSV3.In situ hybridization for EBV was negative.No recurrence or progression could be seen 17 months after surgical therapy.Conclusions Not all tumors derived from Langerhans cell with sarcomatoid features are high grade malignancy;there perhaps exists a subgroup of low grade malignant tumor derived from langerhans cell." @default.
- W2361489054 created "2016-06-24" @default.
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- W2361489054 date "2013-01-01" @default.
- W2361489054 modified "2023-09-25" @default.
- W2361489054 title "Tumor derived from Langerhans cell with sarcomatoid features and favorable clinical course in thoracic vertebrae" @default.
- W2361489054 hasPublicationYear "2013" @default.
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