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- W2361497647 abstract "Aim:To evaluate the safety of glufosfamide in Beagle dogs.Methods:The safety of glufosfamide in Beagle dogs following single iv and multiple iv administration for 3 months was observed.Results:The minimum lethal dose of glufosfamide was 100 mg/kg.The maximum non-lethal dose of glufosfamide was 50 mg/kg.The approximate lethal dose of glufosfamide was 75-100 mg/kg.No serious adverse reactions was observed in Beagle dogs following multiple iv administration once a week for 3 months at the dose of 20 mg/kg,40 mg/kg,and 60 mg/kg.However,organ injury was observed extensively in the high dose-group and mediumt-dose group.The low-dose group showed a light change in individual organs.Conclusion:Under the experimental conditions,40 mg/kg and 60 mg/kg iv administration once a week for 3 months can lead to extensive organ injury in Beagle dogs,so the dose shouldn′t be higher than 20 mg/kg." @default.
- W2361497647 created "2016-06-24" @default.
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- W2361497647 date "2009-01-01" @default.
- W2361497647 modified "2023-09-26" @default.
- W2361497647 title "Toxicity of glufosfamide in Beagle dogs following intravenous injection" @default.
- W2361497647 hasPublicationYear "2009" @default.
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