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- W2361514692 abstract "Objective To study the neuroprotection and mechanism of high dose Danxingtongluotang (DX) against cerebral ischemia-reperfusion injury of rats.Methods Fifty SD male rats were divided randomly into 5 groups:control group,model group(ischemia-reperfusion+NS) nimodipine group(nimodipine 10 mg/kg,ischemia-reperfusion + NS),small dose DX group(DX 7.5 g/kg),high dose DX groupCDX 15 g/kg).There were 10 rats in each group.The 5 groups were fed with nimodipine or DX for consecutive 5 d.The content of MDA in serum was measured,the expression of Fas in brain tissue and behavior scores of rats were examined.Results After cerebral ischemia-reperfusion,the content of MDA in serum,expression of Fas in brain tissue and behavior score of model group increased significantly as compared with other groups(P0.05), the content of MDA in serum,the expression of Fas in brain tissue and behavior scores were decreased significantly in high dose DX group than in nimodipine group and small dose DX group (P0.05).Conclusion High dose DX has an obvious protection against ischemia-reperfusion injury probably through decreasing the content of MDA in serum,the expression of Fas in brain tissue and behavior scores of rats." @default.
- W2361514692 created "2016-06-24" @default.
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- W2361514692 date "2011-01-01" @default.
- W2361514692 modified "2023-09-23" @default.
- W2361514692 title "Neuroprotective effect of high dose Danxingtongluotang against cerebral ischemia-reperfusion injury of rats" @default.
- W2361514692 hasPublicationYear "2011" @default.
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