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- W2361523526 abstract "OBJETIVE:The aim of this research is to study the pharmacokinetics andrelative bioavailability of domestic glimepiride tablets. METHOD: A single oraldose of 4mg of domestic and imported glimepiride tablets were given to l8 healthyvolunteers in a randomized crossover design. Plasma concentrations weredetermined by pre-column derivatization HPLC method. RESULTS: The mainpharmacokinetic parameters were:tmax3.44±0.92 and 2.97±0.88h, Cmax296.l±l08.4 and 33l.8±l03.3μg.L-1, t(1/2)ke 8.03±0.0l and 7.73±2.79h, AUC0-t,2307.9±800.9 and 2302.8±794.8μg.h.L-1,AUC0-∞2672.7±990.5 and 2589.l±752.5mg.h.L-1 for domestic and imported tablets, respectively. The relative bioavailabilityof domestic tablets was l02.4%±l9.7% .CONCLUSIONS: The results of statisticsanalysis demonstrated that two tablets were bioequivalent." @default.
- W2361523526 created "2016-06-24" @default.
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- W2361523526 date "2002-01-01" @default.
- W2361523526 modified "2023-09-25" @default.
- W2361523526 title "Pharmacokinetics and Relative Bioavailability of Glimepiride Tablets in Healthy Volunteers" @default.
- W2361523526 hasPublicationYear "2002" @default.
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