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- W2361530744 abstract "The susceptibility of the golden hamster, Mesocricetus auratus, to various types ofMycobacteria has not received a universal agreement. Hauduroy considered that the in-jection of large dose of B.C.G. could lead to the death of these animals, whereas othersfailed to confirm this finding. Others also reported that the golden hamsters failed todevelop skin sensitivity to tuberculin when they were infected with the pathogenic Myco-bacteria. In an attempt to study further these interesting and important problems, theauthor employed the following Mycobacteria for the inoculation of the hamsters: H_(37)Rv,Bovine type RM, BCG, Avian type, M. smegmatis, and Mycobacterium 607. It wasfound after the inoculation of the human and bovine types of Mycobacteria, at first therewas a rapid growth, but by the third weeks, growth practically ceased, although most ofthe animals finally succumbed to the infection. Those animals inoculated with theAvian type and BCG showed definite multiplication of the organisms, but the animalsshowed no ill effects. Microscopically, the lesions consisted chiefly of granulation with-out calcification or progressive changes. These infected animals also failed to show skinsensitization. After the injection of cortison, these animals failed to show the decreasedresistance observed with rabbits similarly treated. In order to study the influence of humoral factors in the resistance of goldenhamsters to Mycobacteria infections, the authors devised two types of culture chambersembedded in the peritoneum of the animals. The chambers were so constructed as toallow protein molecules of varying sizes to pass into the chamber and at the same timewithholding the cells. It was found with chambers of two sizes of pores, the human andbovine types failed to multiply whereas the non-pathogenic types could grow in chamberswith smaller pores. In contrast, the human and bovine types could multiply in chamberswith large pores when embedded in the peritoneal sacs of the rabbits. From the resultspresented, the author suggested that the humoral factors in the golden hamsters possesssome inhibiting activity against the virulent Mycobacteria of the human and bovinetypes which may contribute to the partial resistance of these animals to Mycobacteriainfection." @default.
- W2361530744 created "2016-06-24" @default.
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- W2361530744 date "1963-01-01" @default.
- W2361530744 modified "2023-09-24" @default.
- W2361530744 title "STUDIES ON THE SUSCEPTIBILITY OF GOLDEN HAMSTERS TO VARIOUS TYPES OF MYCOBACTERIA" @default.
- W2361530744 hasPublicationYear "1963" @default.
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