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- W2361551350 abstract "Objective: To observe the age-related changes in sign and symptoms, and learning and memory of senescence accelerated mouse SAMP8. Methods: Senescence Accelerated Mouse SAMP8 and normal control SAMR1 at six ages from 2th month to 12th month were selected, and age-related changes in and learning and memory were studied by the scores of aging and Water Morrris Maze. Results: The SAMP8 appeared obvious sign and symptoms at 4-month old. Compared to SAMR1 control group, SAMP8 mouse showed significant impairments on learning and memory in hidden platform trial at age of 8th month, 10th month and 12th month. In probe trial and reversal trial, SAMP8 began to show significant impairments on learning and memory at age of 6month. Conclusions: The results showed that SAMP8 began to accelerate senescence after mature period (4-6month) and appeared learning and memory disorder at 6-8 months old. It manifested that SAMP8 was an ideal model for investigation on the mechanism of and senile dementia." @default.
- W2361551350 created "2016-06-24" @default.
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- W2361551350 date "2008-01-01" @default.
- W2361551350 modified "2023-09-24" @default.
- W2361551350 title "Age-related Changes in Behavior of Senescence Accelerated Mouse SAMP8" @default.
- W2361551350 hasPublicationYear "2008" @default.
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