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- W2361551982 abstract "[Objective] To investigate the changes of the fibrinolytic system in patients undergoing mechanical heart valve replacement surgery during cardiopulmonary bypass (CPB) and discuss the measures of its protection. [Methods] To select 20 cases of patients of ASA physical statusⅡ~Ⅲ undergoing mechanical heart valve replacement surgery. Blood samples were taken from jugular vein to assay platelet count (PLT), activated coagulation time (ACT), tissue-type plasminogen activator(t-PA), plasminogen activator inhibitor (PAI) and D-dimer before anesthesia (T1), before heparinization (T2), before CPB, after arteriae aorta unclamp, 10 min after CPB and 2, 24, 48 h after operation. [Results] Compared with those before anesthesia, PLT and AT-III significantly decreased during operation and 2, 24, 48 h after operation(P 0.05, P0.01). ACT significantly decreased 48 h after operation (P 0.05). PT and APTT significantly increased at the T4 and T5(P 0.01), but they significantly decreased at the T7(P 0.05). The t-PA significantly increased at the T3～T6(P 0.01), it recovered to the level of pre-anesthesia at the T7. PAI suddenly decreased at the T3,then it elevated progressively after operation but was lower (P 0.01) than that at the T7 time point. D - Dimer significantly increased at the T3～T7 (P 0.01), while there were descending tendency at the T6,but it significantly increased at the T7 compared with T6 point (P 0.01). [Conclusions] This study shows that there is an activation of the fibrinolytic system during perioperation in patients undergoing mechanical heart valve replacement surgery and an increase of fibrinogen degradation product after CPB, thus interferes blood coagulation." @default.
- W2361551982 created "2016-06-24" @default.
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- W2361551982 date "2008-01-01" @default.
- W2361551982 modified "2023-09-25" @default.
- W2361551982 title "Change of fibrinolytic system during perioperation in patients undergoing mechanical heart valve replacement surgery" @default.
- W2361551982 hasPublicationYear "2008" @default.
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