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- W2361569479 abstract "Killinfunctions in p53-mediated S phase arrest and apoptosis in the absence of p21,pumaand bax were reported.Through co-transfection of EGFP-PCNA and RFP-killin plasmids into cosE5 cells,It was shown that Killin and PCNA exhibit in mutually exclusive pattern in the nucleus during S phase.Consistent with previous finding using BrdU labeling,these results confirm that Killin may function in S-phase checkpoint control.Surprisingly,we also observe that Killin localizes mostly in cell nucleolus in non-S phase cells,suggesting apotential role of Killin in negative regulation of rRNA biogenesis.Thus,as a major p53 target gene,killin may mediate p53 functions in multiple cell cycle checkpoints." @default.
- W2361569479 created "2016-06-24" @default.
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- W2361569479 date "2015-01-01" @default.
- W2361569479 modified "2023-09-25" @default.
- W2361569479 title "Mechanism of killinin p53 mediated cell cycle regulation and its cell cycle specific distribution" @default.
- W2361569479 hasPublicationYear "2015" @default.
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