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- W2361572204 abstract "Objective To label rabbit bone marrow-derived mesenchymal stem cells (MSCs) with superparamagnetic iron oxide particles (SPIO) and study the effects of magnetic labeling on the proliferation and differentiation of MSCs Methods Rabbit MSCs were isolated,purified,expanded,then incubated with various doses of SPIO complexed to protamine sulfate (Pro) transfection agents for 12 h Prussian blue staining and transmission electron microscopy were performed to show intracellular iron Cell viability and differentiation were evaluated Vials containing cells underwent 15T MR imaging (MRI) with GRE T2WI weighted and SE T2WI sequence,and the signal intensity were measured and statistically analyzed Results Intracytoplasmic nanoparticles were confirmed by Prussian blue staining and transmission electron microscopy As compared with the unlabeled cells,no significant difference was found in cell viability,growth rate and differentiation of the labeled MSCs GRE T2WI and T2WI demonstrated significant decrease of signal intensity (SI) in vials containing 1×106 and 5×105 labeled cells,in comparison with unlabeled cells (P0.05) The percentage change of SI (△SI) was significantly higher in 1×106 labeled cells than that in 5×105 labeled cells,particularly on GRE T2WI (P0.05) Among pulse sequences,GRE T2 demonstrated the highest △SI ut significant (P0.05) Conclusion MSCs can be labeled with Fe-Pro efficiently witho change in cell viability and differentiation capacity Visualization of SPIO-labeled MSCs by 15T MRI is feasible" @default.
- W2361572204 created "2016-06-24" @default.
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- W2361572204 date "2008-01-01" @default.
- W2361572204 modified "2023-09-24" @default.
- W2361572204 title "Biological characteristics and in vitro MRI of superparamagnetic iron-oxide labeled bone-derived mesenchymal stem cells from rabbits" @default.
- W2361572204 hasPublicationYear "2008" @default.
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