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- W2361573102 abstract "Objective To prepare baicalin-loaded polyethylene glycol(PEG)-modified solid lipid nanoparticles. Methods The baicalin-loaded solid lipid nanoparticles was prepared by emulsification-solidification method and was modified by PEG1500,PEG2000,PEG4000,PEG6000,respectively.The optimum modification was obtained with the entrapment efficiencies,particle size,state and stability as references. Results PEG2000-modified solid lipid nanoparticles was the best.The photoelectron microscope showed that the particles was spherical in shape.Its encapsulation efficiency,drug-loading capacity,average particle size,zeta potential was 35.51%,1.42%,27.75nm and-15.47 mV,respectively. Conclusion PEG2000-modified solid lipid nanoparticles is better for quality evaluation,which provides the foundation for further preparation of the brain targeting nanoparticles." @default.
- W2361573102 created "2016-06-24" @default.
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- W2361573102 date "2012-01-01" @default.
- W2361573102 modified "2023-09-23" @default.
- W2361573102 title "Preparation of Baicalin-loaded PEG-modified Solid Lipid Nanoparticles" @default.
- W2361573102 hasPublicationYear "2012" @default.
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