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- W2361579551 abstract "PURPOSE: The goal of this investigation is to detect the level of Th1/Th2 type cytokines in serum of SD ratswith squamous cell carcinoma of the tongue and to explore the relationship between the level and tumor progression.METHODS: Among 80 SD rats fed by 0.002% 4- nitroquinoline- 1- oxide (4NQO) drinking water for 36 weeks, 61 withSCC of the tongue had been found and divided into three groups according to the volume of tumor in the base of tongue.Another 20 rats fed by normal water were as control. Peripheral serum was collected. Secretion of Th1- type cytokines,such as IFN-γ, IL- 2 and Th2- type cytokines, such as IL- 4, IL- 10 were detected by enzyme- linked immunosorbent assay(ELISA). The data was processed by analysis of variance statistically. RESULTS: With tumor in tongue base growing,thelevels of IFN-γin peripheral serum decreased gradually. There was significant difference between group of tumordiameter5mm and control group (P0.05), as well as group of tumor diameter≥5mm and control group (P0.05). Thelevel of IL-2 hadn’t been detected in three abnormal groups, but the mean level in the control group was(24.13±15.12)pg/ml.The difference was statistically significant between abnormal groups and control group (P0.05). With the mass in thetongue base enlarging, the concentrations of IL- 4 and IL- 10 increased gradually. As for IL- 4, there was no differencebetween each group (P0.05), whereas the difference of IL- 10 was significant (P0.05). CONCLUSION: There is asignificant positive correlation between shift of Th1/Th2 type cytokines and tumor progression in SD rats with tongue SCC. Supported by Science and Technology Research Fund of Bureau of Shanghai Municipality (Grant No. 014319359)." @default.
- W2361579551 created "2016-06-24" @default.
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- W2361579551 date "2005-01-01" @default.
- W2361579551 modified "2023-09-26" @default.
- W2361579551 title "Shift of Th1/Th2 type serum cytokines in SD rats with squamous cell carcinoma of the tongue and its correlation to tumor progression" @default.
- W2361579551 hasPublicationYear "2005" @default.
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