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- W2361581502 abstract "Objective To explore the changes in the signal transduction pathway of hypothalamic and gastrointestinal receptors as well as the effect mechanism on digestive disturbance in depression treated with electroacupuncture( EA) at Baihui( GV20),Yintang( EX- HN3) and Tianshu( ST25) in terms of the important regulatory factors such as cAMP,PKA and PKC. Methods Forty male SD rats were randomized into a normal group,a model group,a control group and an EA group,10 rats in each one. The radioisotope method was used to observe cAMP level,activity of PKA and PKC in hypothalamus,antrum and jejunum,as well as the intervention of EA at Yintang( EX- HN3),Baihui( GV20) and Tianshu( ST25). Results In the model group,cAMP level and PKA activity in hypothalamus,antrum and jejunum were lower apparently than those in the normal group in the rats,PKC activity was higher apparently than that in the normal group,indicating the significant difference( P 0. 01). The cAMP level and PKA activity in EA group and the control group were all increased apparently than those in the model group,but PKC activity was reduced apparently than that in the model group. The differences were significant in comparison of these two groups with the model group( P 0. 01). The difference was not significant between EA group and the control group. Conclusion The posterior signal transduction pathway,cAMP and PKA were down- regulated and PKC was up- regulated in hypothalamus,antrum and jejunum in the model rats of depression. EA treats digestive disturbance in depression,which is likely related to its regulatory effect on cAMP,PKA and PKC signal transduction." @default.
- W2361581502 created "2016-06-24" @default.
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- W2361581502 date "2014-01-01" @default.
- W2361581502 modified "2023-09-25" @default.
- W2361581502 title "Regulatory Effect of Electroacupuncture on cAMP,PKA and PKC in Hypothalamus and Gastrointestinal Tract in the Model Rats of Chronic Stress" @default.
- W2361581502 hasPublicationYear "2014" @default.
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