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- W2361587690 abstract "Objective: To detect the frequencies of B cell reaction to human collagen type (HC) in synovial fluid and peripheral blood in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). ZMethods: The enzymelinked immunospot (ELISPOT) assay was used for enumerating antiHC immunoglobulin secreting cells (antiHC ISC) after highly efficient polyclonal B cell stimulation with the thymoma cells line (clone OUr BUr) in conjunction with PMA and recombinant human IL2. Results:TBZA low level, but significantly of human collagen specific B cell reaction was found in SFMC of RA patients after stimulation with EL4 thymoma cells together with PMA and rIL2, however, this polyclonal activation was inefficiency in SFMC of OA patients. Similar ratios were found for cells that expressed CD19 or CD20 in both RA and OA patients after stimulation of PBMC and SFMC with EL4/rIL2/PMA, however, the number of CD5+ B cell was increased in both RA synovial fluid and peripheral blood. Specificity analysis demonstrated that B cell reaction with HC in SFMC of RA patients was strongly inhibited by antiHC antibody but not by isotype matched antiHCII antibody in both ELISA and ELISPOT assays. WTHZConclusion: (1)antibody against type collagen in RA patients have pathogenic potential, however, this collagen specific B cell response only can be found in a very sensitive assay and a very sufficient stimulation. (2) CD4+EL4 OUr BUr/rIL2/PMA is efficient for activation of CD5+ autoantibody producing cells." @default.
- W2361587690 created "2016-06-24" @default.
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- W2361587690 date "1999-01-01" @default.
- W2361587690 modified "2023-09-25" @default.
- W2361587690 title "Detection and specificity analysis of B cell response to human collagen type in peripheral blood and synovial fluid of patients with rheumatoid arthritis" @default.
- W2361587690 hasPublicationYear "1999" @default.
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