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- W2361594083 abstract "Objective To investigate the pathological changes in rat brain after immuned by hippocampal tissue,and provide a new experimental method for the study of hippocampal function.Methods The fresh guinea pig hippocampal tissue was applied as antigen to immune SD rats for establishment of animal models,behavioral observations and the use of immunohistochemical staining were done to detect the expression of Arc/Arg3.1.Results Behavior observed abnormal excitement,irritability performance in model group,while no obvious abnormalities in control group.In hippocampal CA3 area of the model group,the expression of Arc/Arg3.1 positive cells was higher than that in the normal control group.The hippocampus dentate gyrus had no obvious expression of Arc/Arg3.1 positive cells in both control and model groups.Conclusion The abnormal excitement and irritability of the rats in model group may be related to the performance of some of the hippocampal homogenate antigen stimulation.The increased expression of Arc/Arg3.1 may be a marker for a series of biochemical reactions by the stimulation in the hippocampus." @default.
- W2361594083 created "2016-06-24" @default.
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- W2361594083 date "2010-01-01" @default.
- W2361594083 modified "2023-09-26" @default.
- W2361594083 title "Features of Arc/Arg3.1 expression in rat brain immuned with hippocampal tissue homogenate from guinea pig" @default.
- W2361594083 hasPublicationYear "2010" @default.
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