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• W2361601660 abstract "Objective To compare side-effects of 2 different preparations of asparaginase(ASP) and polyethylene glycol conjugated asparaginase(PEG-ASP) in treatment of childhood acute lymphoblastic leukemia(ALL),in order to detect and avoid them in time so as to improve the chemotherapy′s safety.Methods One hundred and thirty-five cases of ALL adopted in Qingdao University Medical College Affiliated Hospital from Apr.2009 to Jul.2011 were retrospectively analyzed.Two different preparations of asparaginase were randomly given to ALL children during the remission induction and early consolidation therapy phases,and the clinical manifestations and relevant laboratory reports were observed and analyzed by χ2 test and t-test.Results Both of the ASP and PEG-ASP could inhibit the bone marrow proliferation and the degree of depressant effect was of no statistical significance.The recovery time of leukocyte,granulocyte,hemoglobin,platelet and bone marrow proliferation inhibition during remission induction phases in ASP group were(18.00±5.91) d,(19.70±6.00) d,(21.74±6.97) d,(18.51±8.66) d,(24.04±6.02) d,respectively;In PEG-ASP group they were(26.80±6.23) d,(26.40±6.06) d,(30.40±7.31) d,(17.50±8.30) d,(30.30±5.52) d,respectively.During early consolidation therapy phases in ASP group they were(15.55±3.32) d,(16.68±6.00) d,(2.84±6.58) d,(6.73±8.89) d,(16.61±5.02) d,respectively;In PEG-ASP group they were(23.13±13.65) d,(23.78±10.95) d,(11.82±12.61) d,(2.82±7.30) d,(28.12±6.47) d,respectively.Fibrinogen,activated partial thromboplastin time and antithrombin Ⅲ recovery time,remission induction phases: ASP group were(14.57±7.13) d,(12.15±7.91) d,(12.38±8.15) d,respectively;PEG-ASP group were(29.70±5.36) d,(24.60±11.37) d,(29.30±8.41) d,respectively.Early consolidation therapy phases: ASP group were(11.24±2.90) d,(11.64±2.01) d,(7.13±3.71) d,respectively;PEG-ASP group were(29.46±7.25) d,(19.05±9.26) d,(30.26±8.56) d,respectively;they were statistically significant,which indicated that PEG-ASP had a longer inhibition in blood clotting routine.The allergy incidence,the low total protein and hypoalbuminemia,during remission induction phases in ASP group were 3.77%,56.6%,22.64%,respectively,while in PEG-ASP group they were 0.00%,100.00%,60.00%,respectively;durign early consolidation therapy phases in ASP group were 21.21%,57.58%,30.30%,respectively,while in PEG-ASP group they were 2.56%,84.61%,64.10% respectively.Conclusions Both of the ASP and PEG-ASP can inhibit the bone marrow proliferation and the degree of depressant effect is of no statistical significance;The protein synthesis inhibition is bigger in PEG-ASP group than in ASP group,the recovery time of blood routtine,blood clotting routine and bone marrow proliferation inhibition in PEG-ASP group is longer than those in ASP group,which indicates that PEG-ASP can play a longer role in vivo than ASP;the allergy incidence of ASP is higher than that of PEG-ASP,the other side-effects about 2 different preparations of asparaginase are similar." @default.
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• W2361601660 date "2012-01-01" @default.
• W2361601660 modified "2023-09-28" @default.
• W2361601660 title "Comparisons of Side-Effects and Countermeasures for Two Different Preparations of Asparaginase in Treatment of Acute Lymphoblastic Leukemia" @default.
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