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- W2361618375 abstract "Objective To observe the effects of nimodipine on expression of tumor necrosis factor(TNF)-α,interleukin(IL)-1βand IL-6 of the sciatic nerve following subarachnoid hemorrhage(SAH) in rats.Methods SD rats were randomly divided in three groups of control group(n=10),SAH group(n=15) and nimodipine group(n=15).Nimodipine was intravenouly injected in nimodipine group via vena caudalis from the 1st to 14th day.The sciatic nerve samples were taken on the 3rd,7th and 14th day for detecting the expressions of TNF-α,IL-1β and IL-6 using immunocytochemistry.Results The expressions of TNF-α,IL-1βand IL-6 on the 3rd,7th and 14th day were significantly higher in SAH group than those in control group(P0.05).The expressions of TNF-α,IL-1βand IL-6 on the 3rd and 7th day were significantly higher in SAH group than those in nimodipine group(P0.05),and the difference of IL-1β and IL-6 expressions between the two groups was still significant on the 14th day.Conclusion The expressions of TNF-α,IL-1βand IL-6 are increased in the sciatic nerves following SAH in rats,which may be reduced by nimodipine intervention." @default.
- W2361618375 created "2016-06-24" @default.
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- W2361618375 date "2009-01-01" @default.
- W2361618375 modified "2023-09-28" @default.
- W2361618375 title "Effect of nimodipine on expression of TNF-α,IL-1βand IL-6 of sciatic nerve following subarachnoid hemorrhage in rats" @default.
- W2361618375 hasPublicationYear "2009" @default.
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