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- W2361621370 abstract "Aim To determine cyclosporin A content and study the release behavior of cyclosporin A submicron emulsion.Methods The HPLC method was established to determine the content of cyclosporin A in the emulsion. Zorbax SB-C18 column was used as the analytical column with a temperature of 70℃. The mobile phase consisted of acetonitrile and 0.5% phosphonic acid solution at the ratio of 75∶25(v/v). The UV detection wavelength was set at 210nm. The positive and reverse dialysis bag techniques were performed to determine the release profiles of cyclosporin A in vitro,and the effect of different rotating speed on drug release was studied. Results The linear range was from 20.0μg·ml-1 to 1 000.0μg·ml-1 (r =0.999 9) and the average recovery rate was 99.7%. The RSD within-day and between-day was 0. 15% and 0. 72%,respectively. The results of release tests showed that cyclosporin A was released more rapidly by reverse dialysis technique than the positive one. The release rate increased obviously with the increase of rotating speed.Conclusion The method was simple,accurate and reliable for the determination of cyclosporin A. The reverse dialysis technique could save time and preferably simulate the release behavior of cyclosporin A emulsion." @default.
- W2361621370 created "2016-06-24" @default.
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- W2361621370 date "2008-01-01" @default.
- W2361621370 modified "2023-09-25" @default.
- W2361621370 title "Content Determination and in Virto Release Characteristic of Cyclosporin A Submicron Emulsion for Ocular Administration" @default.
- W2361621370 hasPublicationYear "2008" @default.
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