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- W2361622028 abstract "Objective To investigate the effect of the antisense oligodeoxynucleotides of human cyclooxygenase-2(COX-2 AS-ODNs) in inhibiting cervical cancer cell line Hela proliferation. Methods The Hela cells were cultured in vitro and were divided into 6 groups: control group(A),cultured in MEM;Sense-ODNs group(B),were cultured in COX-2 10 μmol/l AS-ODNs+lipofectin+Opitin-MEM;Lipo group(C) (transfected with Lipofectin only),D1 group(transfected with 5μmol/l COX-2 AS-ODN+Lipo/well),D2 group(transfected with 10 μmol/l COX-2 AS-ODN+Lipo/well),and D3 group(transfected with 15μmol/l COX-2 AS-ODN+Lipo/well).(1)The proliferative status of transfected cells was measured by using methabenzthiazuron(MTT) assay to detect the alive Hela cells in,24,48,72,96 and 120 hours after the transfection,and cell proliferation curve according to the OD number.Results The lipoferation of the transfected Hela cells was significantly inhibited in the COX-2 AS-ODN group,in the AS-ODNs transfected cells,the proliferative index decreased significantly with the increasing of COX-2 AS-ODNs concentration.The effect of COX-2 AS-ODN was strongest by the 48～72 hour after transfection and then began to decrease and basically disappeared 120 hours after.if no AS-ODNs is supplied.Conclusion Transfection with antisense ODNs of human COX-2 mRNA could inhibit the proliferation of human cervical cancer Hela cells." @default.
- W2361622028 created "2016-06-24" @default.
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- W2361622028 date "2006-01-01" @default.
- W2361622028 modified "2023-09-24" @default.
- W2361622028 title "The inhibition effection of Hela cell proliferation of cervical carcinoma by cyclooxygenase-2 antisense oligodeoxynucleotides" @default.
- W2361622028 hasPublicationYear "2006" @default.
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