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- W2361637566 abstract "Objective: To research the protection effect of Ningshen Granula on kidney of rats with IgA nephropathy, and the inl uence on the expression of platelet derived growth factor-BB(PDGF-BB), and to investigate the therapeutic mechanism of Ningshen Granula for IgA nephropathy. Methods: Thirty-two rats were randomly divided into control group, model group, Ningshen Granula low-dose(12g/kg) and high-dose groups(24g/kg). The IgA nephropathy rat model was established according to the method of intragastric administration with lipopolysaccharide, bovine serum albumin and carbon tetrachloride. After the models were established, the rats of the four groups were administered in the morning and evening on every day for consecutive 4 weeks. The red blood cell in urine, 24 hours protein quantitative, renal pathology structure and immunopathogenesis were tested. The Western blot was used to test the expression of PDGF-BB. Results: Compared with the control group, the red blood cell in urine, 24 hours protein quantitative, proliferation of glomerular mesangial area and intensity of glomerular IgA immunol uorescence of the rats in the model group increased signii cantly, and the expression of PDGF-BB of renal tissue increased(P0.05, P0.01). Compared with the model group, the red blood cell in urine, 24 hours protein quantitative and intensity of glomerular IgA immunol uorescence of the rats in Ningshen Granula low-dose and high-dose groups were decreased(P0.05, P0.01). Compared with the model group, proliferation of glomerular mesangial area and expression of PDGF-BB protein of renal tissue in Ningshen Granula high-dose group were decreased signii cantly(P0.01). Conclusion: Ningshen Granula could protect the kidney of IgAN rats, and the mechanism might be related to the inhibition of the up-regulation expression of PDGF-BB in renal." @default.
- W2361637566 created "2016-06-24" @default.
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- W2361637566 date "2014-01-01" @default.
- W2361637566 modified "2023-09-24" @default.
- W2361637566 title "Influence of Ningshen Granula on the protection effect of rats with IgA nephropathy and the expression of PDGF-BB in renal tissues" @default.
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