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- W2361640411 abstract "Objective:To optimize and characterize the liposomal retinoic acid.Methods:The li- posomal retinoic acid was prepared by reverse evaporation followed by microfludic technology;the concen- tration and encapsulation efficiency of retinoic acid in the liposomes were determined by high performance liquid chromatography;the particle shape and size and distribution of liposomal retinoic acid were assessed by transmission electrical microscope and photon correlation spectroscopy.Results:The total concentration of phospholipids and cholesterol was 40～50 mg·mL~(-1)(3%～4% of total weight).At the mass ratio of phospholipids and cholesterol 3:1～4:1,the encapsulation efficiency of liposomal retinoic acid reached a- round 90%.The average particle size of liposomal retinoic acid was at 700～800 nm.The retinoic acid was mostly in large unilamellar vesicles with ploydispersity index(PI)below 0.3.Conclusion:The homogene- ous liposomal retinoic acid was achievable." @default.
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- W2361640411 date "2006-01-01" @default.
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- W2361640411 title "Preparation and characteristics of liposomal retinoic acid" @default.
- W2361640411 hasPublicationYear "2006" @default.
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