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- W2361661540 abstract "Objective:To investigate the effects of antipsychotic agents (APS) therapy on glucose regulation and the relationship with index of weight and body fat distribution in previously untreated patients with schizophrenia. Method:Fasting and 2-hour after breakfast plasma glucose levels were measured in 46 Chinese Han untreated patients with schizophrenia receiving risperidone or chlorpromazine before and after 10-week treatment.Body weight, body mass index (BMI) and waist-hip-ratio (WHR) were also measured for whole subjects.Abdominal body fat was determined by MRI in 40 of schizophrenic patients before and after 10-week treatment. Results:There was a significant elevation in 2-hour breakfast plasma glucose levels in schizophrenic patients after 10-week treatment compared with untreated patients,with a substantial increase in morbidity of IGT. Before treatment,after 2-hour breakfast plasma glucose level was positively correlated with index of weight and body fat distribution.However,Such correlation disappeared after 10-week treatment. Conclusion:APS acute treatment may impair glucose regulation of schizophrenic patients. Abnormality of glucose regulation correlated with change of weight and body fat distribution." @default.
- W2361661540 created "2016-06-24" @default.
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- W2361661540 date "2004-01-01" @default.
- W2361661540 modified "2023-09-23" @default.
- W2361661540 title "Investigation into antipsychotic agents related changes of glucose regulation and the relationship with index of weight and body fat distribution" @default.
- W2361661540 hasPublicationYear "2004" @default.
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