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- W2361661787 abstract "Sirolimus and its immunosuppressive regimens have been used for preventing rejection after kidney transplantation. This review analyzes their merits and demerits comparing with other conventional regimens from the aspects of acute rejection rate, graft function, as well as graft survival rates. As conclusion, sirolimus is mostly recommended to be used as conversion therapy after kidney transplantation. Minimization or withdrawal of cyclosporine A(CsA) could also be considered when they were combined with SRL, while SRL concentration should be controlled. SRL can replace mycophenolate mofetil(MMF), and the calcineurin inhibitors(CNIs) should be reduced appropriately in this setting. Initiated low dose of CNI combined with SRL has no apparent merits and thus is not recommended. Initiated then maintained standard dose of CNI combined with SRL, initiated non-CNI regimens as well as SRL use in DGF patients should be avoided. Sirolimus can support steroids withdrawal after kidney transplantation, and SRL combined with tacrolimus is recommended in this setting. Loading dose is recommended when initiating SRL treatment and its trough blood level should be routinely monitored." @default.
- W2361661787 created "2016-06-24" @default.
- W2361661787 creator A5090550973 @default.
- W2361661787 date "2014-01-01" @default.
- W2361661787 modified "2023-09-28" @default.
- W2361661787 title "Immunosuppressive regimens for sirolimus-treated renal transplant recipients: which one is the best?" @default.
- W2361661787 hasPublicationYear "2014" @default.
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