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- W2361666887 abstract "Eight rabbits were divided into two groups,and after single oral gavage diclazuril and diclazuril microcapsule(equivalent to diclazuril 20 mg/kg),blood was collected in the set time points and determined by HPLC.The pharmacokinetic parameters were calculated by DAS2.0 pharmacokinetic software.Pharmacokinetics of diclazuril intestines dissolving microcapsules was studied in the rabbit plasma after single oral gavage.The results showed that the mean concentration-time curves of diclazuril and reference preparation were fitted to the two-compartment model with the main pharmacokinetic parameters as follows:Cmax were(58.541±0.021) μg/mL and(76.738±0.073) μg/mL respectively;T1/2Ka were(3.451±0.089) h and(11.957±0.375) h respectively;T1/2β were(26.088±0.177) h and(29.523±0.219) h respectively;AUC(0-∞) were(4 129.138±13.546)(μg/mL)·h and(6 017.061±16.872)(μg/mL)·h respectively,MRT(0-∞) were(64.011±0.44) h and(75.904±0.623) h respectively.Compared with the original drug solution,the peak time of microcapsules was significantly delayed,and the peak concentration increased,while the mean residence time of drugs in rabbits was longer than that of original drug.After diclazuril microencapsulation,the effect was longer than that of original drug,and bioavailability was significantly improved." @default.
- W2361666887 created "2016-06-24" @default.
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- W2361666887 date "2013-01-01" @default.
- W2361666887 modified "2023-09-26" @default.
- W2361666887 title "Pharmacokinetics of diclazuril intestines dissolving microcapsules in rabbits" @default.
- W2361666887 hasPublicationYear "2013" @default.
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