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- W2361667362 abstract "Objective:To study the effect of ASA on brain I/R injury in rats. Methods: Sixty male SD rats were randomized in the sham operation,control,ASA 10 mg/kg,ASA 40 mg/kg and ASA 160 mg/kg groups. MCA occlusion was achieved by advancing a nylon filament into the internal carotid artery. After MCA occlusion for 2 hours and reperfusion for 22 hours,the neutrophil infiltration,the activity of NF-κB,the expression of TNF-α,IL-1β and ICAM-1 in brain tissue,the infarct volume and the neurologic deficit were studied. Results: The ASA inhibited the neutrophil infiltration,activity of NF-κB,the expression of ICAM-1,IL-1βand TNF-α,reduced the infarct volume(ASA10 and 40 mg/kg were more efficient),but yielded no effects on neurologic deficit scores. Conclusions: ①ASA reduced the brain I/R injury,which is more efficient with low dose. ②There was an acute inflammation in brain ischemic reperfusion,which could be inhibited by ASA. Such inhibition might give rise to a reduction of brain I/R injury. ③As the treatment efficacy with low dose ASA is more significant,it is suggested that the neuroprotection of ASA is related to the improvement of cerebral blood flow during brain ischemic reperfusion." @default.
- W2361667362 created "2016-06-24" @default.
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- W2361667362 date "2002-01-01" @default.
- W2361667362 modified "2023-09-25" @default.
- W2361667362 title "Effect of ASA on Brain I/R Injury in Rats" @default.
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